Language With Forkhead Poem by Kyungdae Min

Language With Forkhead - Poem by Kyungdae Min



This gene encodes a member of the forkhead/winged-helix (FOX)family of transcription factors. It is expressed in fetal
and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX
DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may
bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety
of genes. This gene is required for proper development of speech and language regions of the brain during
embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence
language development. Mutations in this gene cause speech-language disorder 1 (SPCH1) , also known as autosomal
dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different
isoforms have been identified in this gene.